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Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia.doc

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Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia

Annals of General Psychiatry BioMedCentral Primary research Open Access Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia Monte S Buchsbaum*1, Peter Schoenknecht2, Yuliya Torosjan1, Randall Newmark1, King-Wai Chu1, Serge Mitelman1, Adam M Brickman3, Lina Shihabuddin1, M Mehmet Haznedar1, Erin A Hazlett1, Shabeer Ahmed1 and Cheuk Tang4 Address: 1Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA, 2Department of Psychiatry, University Hospital Heidelberg, Ruprecht-Karls-University, Heidelberg, Germany, 3Taub Institute for Research on Alzheimers Disease and the Aging Brain, College of Physicians and Surgeons. Columbia University, New York, New York, USA and 4Department of Radiology, Mount Sinai School of Medicine, New York, New York, USA Email: Monte S Buchsbaum* - monte.buchsbaum@; Peter Schoenknecht - Peter.Schoenknecht@med.uni-heidelberg.de; Yuliya Torosjan - yuliya.torosjan@; Randall Newmark - randall_newmark@; King-Wai Chu - kingwai.chu@; Serge Mitelman - simitelman@; Adam M Brickman - ambrickman@; Lina Shihabuddin - linashihabuddin@; M Mehmet Haznedar - Mehmet.Haznedar@; Erin A Hazlett - erin.hazlett@; Shabeer Ahmed - shabeer88@; Cheuk Tang - Cheuk.Tang@ * Corresponding author Published: 28 November 2006 Received: 17 February 2006 Accepted: 28 November 2006 Annals of General Psychiatry 2006, 5:19 doi:10.1186/1744-859X-5-19 This article is available from: /content/5/1/19 ? 2006 Buchsbaum et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract We acquired diffusion tensor and structural MRI images on 103 patients with schizophrenia and 41 age-matched normal controls. The vector data was used to trace tracts from a region of interest in the anterior limb