Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.docVIP

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Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.doc

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Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis

Open Access Re rch 2005ElkonetVoal.lumesea6, Issue 5, Article R43 Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis ¤ ¤ Ran Elkon *, Sharon Rashi-Elkeles *, Yaniv Lerenthal*, Chaim Linhart?, Tamar Tenne*, Ninette Amariglio?, Gideon Rechavi?, Ron Shamir? and Yosef Shiloh* Addresses: *The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. ?School of Computer Science, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. ?Department of Pediatric Hemato-Oncology and Functional Genomics, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. ¤ These authors contributed equally to this work. Correspondence: Yosef Shiloh. E-mail: yossih@post.tau.ac.il Published: 13 April 2005 Received: 29 December 2004 Revised: 3 February 2005 Accepted: 8 March 2005 Genome Biology 2005, 6:R43 (doi:10.1186/gb-2005-6-5-r43) The electronic version of this article is the complete one and can be found online at /2005/6/5/R43 ? 2005 Elkon et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DNAthrpaantsMtdwdamage-inducediucocrpeoriavroorftaatyhlaesntcrdeelsRlsuN-litranscriptionalanArdiruteecsephdonntorslaoensgsitceorsnetworkidwpoteiurobenlaefpaspctintrloiaearndsdhumant(obNrdFeiκasBksescellularac(ntAadTtpMr5a)n3system)wscriptionalmas rdeqatueidrenetworkmd ofosrt othfetinducedhaectdiavmatiaobygne-oDNAinf bdoutcdamagehedpagtehnweinaaycshumant.iva/tpioncells,whilerevealinga major Abstract Background: Gene-expression microarrays and RNA interfe