Differential response to right unilateral ECT in depressed patients impact of comorbidity and severity of illness [ISRCTN39974945].docVIP

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Differential response to right unilateral ECT in depressed patients impact of comorbidity and severity of illness [ISRCTN39974945].doc

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Differential response to right unilateral ECT in depressed patients impact of comorbidity and severity of illness [ISRCTN39974945]

BMC Psychiatry BioMedCentral BMC R 20 e 0 s 2 e Psychiatry, arch article 2 Differential response to right unilateral ECT in depressed patients: impact of comorbidity and severity of illness [ISRCT Pertti Heikman*1, Heikki Katila1, Seppo Sarna2, Kristian Wahlbeck1 and Kimmo Kuoppasalmi3 Address: 1Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland, 2Department of Public Health, University of Helsinki, Helsinki, Finland and 3National Public Health Institute, Helsinki, Finland E-mail: Pertti Heikman* - pertti.heikman@hus.fi; Heikki Katila - heikki.katila@hus.fi; Seppo Sarna - Seppo.Sarna@helsinki.fi; Kristian Wahlbeck - kristian.wahlbeck@hus.fi; Kimmo Kuoppasalmi - kimmo.kuoppasalmi@ktl.fi *Corresponding author Published: 17 January 2002 Received: 17 October 2001 Accepted: 17 January 2002 BMC Psychiatry 2002, 2:2 This article is available from: /1471-244X/2/2 ? 2002 Heikman et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Recent electroconvulsive therapy (ECT) efficacy studies of right unilateral (RUL) ECT may not apply to real life clinics with a wide range of patients with major depressive episodes. Methods: The study included two groups of patients. In addition to a homogeneous group of patients with major depression according to DSM-IV criteria with severity of the major depressive episode 16 scores on 17-item Hamilton Rating Scale for Depression (HDRS) (Group 1, n = 16), we included a heterogeneous group of patients with less severe major depressive episodes or with a variety of comorbid conditions (Group 2, n = 24). We randomly assigned the patients to an RUL ECT treatment dosed at 5 or 2.5 times seizure threshold with an intent-to-treat design. The outcomes measured blindly were HDRS, number of treatments