Drug-drug co-crystals.docVIP

SekhonDARUJournalofPharmaceuticalSciences2012,20:45 /content/20/1/45 EDITORIAL OpenAccess Drug-drugco-crystals BhupinderSinghSekhon Editorial combinationdrugs[3].Themeloxicam-aspirinco-crystal Active pharmaceutical ingredients (APIs) are most con- decreased the time required to reach the human thera- veniently developed and delivered orally as solid dosage peutic concentration compared with the parent drug, forms that contain a defined crystalline form of anAPI. meloxicam [4]. Higher degree of solubility of acetyl- Co-crystalisacrystalline entity formed bytwodifferent salicylic acid: (L)-theanine [(L)-5-N-ethyl-glutamine] or more molecular entities where the intermolecular co-crystal system enables aspirin formulations for intra- interactions are weak forces like hydrogen bonding and venous administration [5]. The 1:1 acetaminophen/ π-πstacking.Co-crystalsareanenablingtechnologythat theophylline(AT)co-crystalhadafasterdissolutionrate is used in new or existing drug delivery systems by than AT physical mixtures [6]. Pharmaceutical compos- majority of pharmaceutical companies in formulation itioncomprisingtherapeuticallyeffectiveamountoflami- and drug development. The concept of modifying the vudine: zidovudine co-crystals use for manufacture of propertiesofadrugmoleculebyformingapharmaceut- medicament for treatment of HIV infections of humans ical co-crystal containing a single APIs and a pharma- wasreported[7].Asinglestepco-depositionofalbuterol ceutical relevant co-former with improved properties sulphate: ipratropium bromide co-crystal aerosols was compared with the pure drug crystal has generated reported [8]. Two 1:1 drug-drug co-crystals [isoniazid: 4- immense interest [1]. Physicians prescribe combination aminosalicylic acid; pyrazinamide: 4-aminosalicylic acid] therapy frequently to treat and manage a plethora of may be exploited for the treatment of tuberculosis [9]. medical conditions. Multi-API co-crystals, relatively Celeco