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Bakal Genome Biology 2012,13:312 /2012/13/1/312 MEE TING REPORT Dynamic systems Chris Bakal* deposited in Array Express, Alvis Brazma (EMBL Euro- pean Bioinformatics Institute) also provided evidence from human cells that most genes are in fact expressed in most cell types. Although there are di?erences in gene expression between di?erent cell types (neuronal, blood, cancer), they are much less than perhaps might be expected from functional or morphological di?erences. Stephen Watt (CRUK Cambridge Research Institute) and Lars D?lken (University of Cambridge) demonstrated the Abstract A report of the Wellcome Trust Functional Genomics and Systems Biology Conference, Hinxton, UK, 29 November to 1 December 2011. One of the central aims of systems-biology is to gain a holistic, quantitative, and predictive understanding of how the complex interplay between genotype and the existence of non-coding RNAs with rapid turnover - environment determines speci?c phenotypes in the species of RNA that probably evaded detection before context of health and disease. Pioneering e?orts over the past decade have led to insights that are impressive in scale but are often static portraits of dynamical cellular systems. Moreover, initial systems-biology research has done little to address how genetic variation impacts cell the development of recent technologies, but that are widely expressed. Whether this abundant gene expression is essential for survival, or rather that exquisite regulation of transcription would waste valuable resources, is still an open question. By creating haploinsu?cient yeast strains, systems architecture and information ?ow. However, Stephen Oliver (University of Cambridge) showed that work presented over 3 days at this conference consistently the genes required for growth are di?erent from