Effects of Yinchenhao Tang and related decoctions on DMN-induced cirrhosisfibrosis in rats.docVIP

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Effects of Yinchenhao Tang and related decoctions on DMN-induced cirrhosisfibrosis in rats.doc

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Effects of Yinchenhao Tang and related decoctions on DMN-induced cirrhosisfibrosis in rats

Chinese Medicine BioMedCentral Research Open Access Effects of Yinchenhao Tang and related decoctions on DMN-induced cirrhosis/fibrosis in rats Cheng Liu1, Mingyu Sun1, Lei Wang1, Gaoqiang Wang1, Gaofeng Chen1, Chenghai Liu1,2,3 and Ping Liu*1,2,3 Address: 1Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, 2Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and 3E-institutes of Shanghai Municipal Education Commission, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Email: Cheng Liu - liucheng0082010@163.com; Mingyu Sun - mysun248@; Lei Wang - laoxia524@163.com; Gaoqiang Wang - wanggaoqiang2003@; Gaofeng Chen - gaofengchen06@126.com; Chenghai Liu - chenghailiu@; Ping Liu* - liuliver@ * Corresponding author Published: 31 January 2008 Received: 16 May 2007 Accepted: 31 January 2008 Chinese Medicine 2008, 3:1 doi:10.1186/1749-8546-3-1 This article is available from: /content/3/1/1 ? 2008 Liu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Chinese medicine decoctions such as Yinchenhao Tang (YCHT), Xiayuxue Tang (XYXT), Huangqi Tang (HQT), Yiguan Jian (YGJ) and Xiaochaihu Tang (XCHT)) were used to treat liver cirrhosis. The present study evaluates the effects of these decoctions on fibrosis in rats induced by dimethylnitrosamine (DMN). Methods: DMN solution (0.5%) was injected to rats for three consecutive days per week for four weeks. At the beginning of week 3, rats were randomly divided into 4-week DMN control group, YCHT, XYXT, HQT, YGJ, XCHT and vehicle groups. Each group was orally administered with specific decoctions daily for two weeks. Rats in the v