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Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients.doc

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Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients

Available online /content/9/1/R18 Research article Open Access Vol 9 No 1 Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients Martin K Andersson1,2, Pernilla Lundberg2, Acke Ohlin3, Mark J Perry4, Anita Lie2, André Stark1 and Ulf H Lerner2 1Department of Orthopaedic Surgery, Karolinska Hospital, Karolinska Institute, 171 76, Stockholm, Sweden 2Department of Oral Cell Biology, Ume? University, Ume?, 901 87, Sweden 3Department of Orthopaedics, Malm? University Hospital, Lund University, Lund, 205 02, Sweden 4Departments of Anatomy and Clinical Sciences North Bristol, University of Bristol, Bristol, BS2 8EJ, UK Corresponding author: Ulf H Lerner, ulf.lerner@odont.umu.se Received: 9 Mar 2006 Revisions requested: 18 Apr 2006 Revisions received: 21 Dec 2006 Accepted: 22 Feb 2007 Published: 22 Feb 2007 Arthritis Research Therapy 2007, 9:R18 (doi:10.1186/ar2127) This article is online at: /content/9/1/R18 ? 2007 Andersson et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Aseptic loosening of a joint prosthesis is associated with remodelling of bone tissue in the vicinity of the prosthesis. In the present study, we investigated the effects of synovial fluid (SF) common gamma subunit) were not affected by either of the two SF types. Bone resorption induced by SFs was inhibited by addition of OPG. Antibodies neutralising interleukin (IL)-1α, IL- 1β, soluble IL-6 receptor, IL-17, or tumour necrosis factor-α, when added to individual SFs, only occasionally decreased the bone-resorbing activity. The mRNA expression of alkaline phosphatase and osteocalcin was increase