Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods.docVIP

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Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods.doc

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Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods

BMC Pregnancy and Childbirth BioMedCentral BMC2002Pregnancy, and Childbirth 2 Research article x Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods Nobue Watanabe* and Masanobu Ohsawa Address: Department of Environmental Health, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan E-mail: Nobue Watanabe* - nobuew@tokyo-eiken.go.jp; Masanobu Ohsawa - osawa@tokyo-eiken.go.jp *Corresponding author Published: 25 March 2002 Received: 31 January 2002 Accepted: 25 March 2002 BMC Pregnancy and Childbirth 2002, 2:2 This article is available from: /1471-2393/2/2 ? 2002 Watanabe and Ohsawa; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any pur- pose, provided this notice is preserved along with the articles original URL. Abstract Background: The possible participation of diesel exhaust inhalation during the fetal period in the elevation of IgE against pollen in postnatal life was investigated. Method: The experiment was conducted using rat pups. Group I; exposed to clean air (Control). Group 2, 3; exposed to total or filtered diesel exhaust during the fetal period (Total-C-C, Filtered-C- C). Group 4, 5; exposed to total or filtered diesel exhaust during the suckling period (C-Total-C, C- Filtered-C). Group 6,7; exposed to total or filtered diesel exhaust during the weaning period (C-C- Total, C-C-Filtered). Total diesel engine exhaust contained 1.73 mg/m3 particulate matter and 0.79 ppm nitrogen dioxide; filtered exhaust contained the same gases as the total exhaust without particulate matter. Intraperitoneal injection of 5 mg crude cedar pollen was performed at 2-week intervals from the 49th day after birth. Results: The mean IgE titers measured by the P-K reaction in the Control, Total-C-C, Filtered-C-C, C- Total-C, C-Filtered-C, C-C-Total and C-C-Fi