Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.docVIP
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Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs
Chinese Medicine
BioMedCentral
Review
Open Access
Enhancement of ATP generation capacity, antioxidant activity and
immunomodulatory activities by Chinese Yang and Yin tonifying
herbs
Kam Ming Ko* and Hoi Yan Leung
Address: Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Email: Kam Ming Ko* - bcrko@ust.hk; Hoi Yan Leung - bclhy@ust.hk
* Corresponding author
Published: 27 March 2007
Received: 9 August 2006
Accepted: 27 March 2007
Chinese Medicine 2007, 2:3
doi:10.1186/1749-8546-2-3
This article is available from: /content/2/1/3
? 2007 Ko and Leung; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Chinese tonifying herbs such as Herba Cistanche, Ganoderma and Cordyceps, which possess
antioxidant and/or immunomodulatory activities, can be useful in the prevention and treatment of
age-related diseases. Pharmacological studies on Yang and Yin tonifying herbs suggest that Yang
tonifying herbs stimulate mitochondrial adenosine triphosphate (ATP) generation, presumably
through the intermediacy of reactive oxidant species, leading to the enhancement of cellular/
mitochondrial antioxidant status. Yin tonifying herbs, however, apart from possessing antioxidant
properties, exert mainly immunomodulatory functions that may boost a weak immune system and
may also suppress overreactive immune responses. The abilities of Yang and Yin Chinese tonifying
herbs to enhance ATP generation and to exhibit antioxidant and/or immunomodulatory actions are
the pharmacological basis for their beneficial effects on the retardation of aging.
Background
tic measures. Humans have been making continuous
efforts to fight aging. As
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