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Enhancement of in vitro interleukin-2 production in normal subjects following a single spinal manipulative treatment.doc

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Enhancement of in vitro interleukin-2 production in normal subjects following a single spinal manipulative treatment

Chiropractic Osteopathy BioMedCentral Research Open Access Enhancement of in vitro interleukin-2 production in normal subjects following a single spinal manipulative treatment Julita A Teodorczyk-Injeyan1, H Stephen Injeyan*2, Marion McGregor1, Glen M Harris3 and Richard Ruegg3 Address: 1Division of Graduate Education and Research, Canadian Memorial Chiropractic College, Canada, 2Division of Foundational and Professional Education, Canadian Memorial Chiropractic College, Canada and 3Division of Clinical Education, Canadian Memorial Chiropractic College, Canada Email: Julita A Teodorczyk-Injeyan - jinjeyan@cmcc.ca; H Stephen Injeyan* - sinjeyan@cmcc.ca; Marion McGregor - mmcgregor@cmcc.ca; Glen M Harris - gharris@cmcc.ca; Richard Ruegg - rruegg@cmcc.ca * Corresponding author Published: 28 May 2008 Received: 16 November 2007 Accepted: 28 May 2008 Chiropractic Osteopathy 2008, 16:5 doi:10.1186/1746-1340-16-5 This article is available from: /content/16/1/5 ? 2008 Teodorczyk-Injeyan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Increasing evidence supports somato-visceral effects of manual therapies. We have previously demonstrated that a single spinal manipulative treatment (SMT) accompanied by audible release has an inhibitory effect on the production of proinflammatory cytokines in asymptomatic subjects. The purpose of this study is to report on SMT-related changes in the production of the immunoregulatory cytokine interleukin 2 (IL-2) and to investigate whether such changes might differ with respect to the treatment approach related to the presence or absence of an audible release (joint cavitation). Methods: Of 76 asymptomatic subjects, 29 received SMT with cavitation (SMT