Enhancement of Epimedium Fried with Suet Oil Based on in Vivo Formation of Self-Assembled Flavonoid Compound Nanomicelles.docVIP

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Enhancement of Epimedium Fried with Suet Oil Based on in Vivo Formation of Self-Assembled Flavonoid Compound Nanomicelles.doc

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Enhancement of Epimedium Fried with Suet Oil Based on in Vivo Formation of Self-Assembled Flavonoid Compound Nanomicelles

Molecules 2012, 17, 12984-12996; doi:10.3390/molecules171112984 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Enhancement of Epimedium Fried with Suet Oil Based on in Vivo Formation of Self-Assembled Flavonoid Compound Nanomicelles Li Cui 1,2,?, E Sun 1,?, Zhen-Hai Zhang 1, Xiao-Bin Tan 1, Ying-Jie Wei 1, Xin Jin 1,2 and Xiao-Bin Jia 1,2, * 1 Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, 100 Shizi Road, Nanjing 210028, Jiangsu, China; E-Mails: cuili2008516@126.com (L.C.); sune0825@ (E.S.); davidpharm@ (Z.-H.Z.); njtxb@ (X.-B.T.); wyj970@163.com (Y.-J.S.); jinxin871211@163.com (X.J.) 2 Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu, China ? These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: xiaobinjia_nj@126.com; Tel.: +86-25-8560-8672; Fax: +86-25-8563-7809. Received: 10 August 2012; in revised form: 5 October 2012 / Accepted: 30 October 2012 / Published: 1 November 2012 Abstract: The purpose of this work was to research the enhancement of Epimedium fried with suet oil based on the in vivo formation self-assembled flavonoid nanomicelles. Taking icariin as the representative, under the action of suet oil, self-assembled nanomicelles were prepared under simulated gastrointestinal tract conditions and were characterized by dynamic light scattering and transmission electron microscopy (TEM). The experiments with icariin self-assembled nanomicelles without suet oil were done according to the above. The influence of suet oil on the transportation of icariin across Caco-2 cell monolayers and the absorption in rat intestine of self-assembled nanomicelles were evaluated. The particle size of icariin self-assembled nanomicelles with suet oil was smaller than without suet oil. The nanomicelles seemed to be monodisperse spherical particle with smooth surfaces. The icarii