Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population.docVIP

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Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population.doc

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Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population

Available online /content/6/5/R415 Research article Open Access Vol 6 No 5 Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population Sheng-Yu Jin*1, Seung-Jae Hong*2, Hyung In Yang3, Sang-do Park3, Myung-Chul Yoo4, Hee Jae Lee1, Mee-Suk Hong1, Hae-Jeong Park1, Seo Hyun Yoon1, Bum-Shik Kim1, Sung- Vin Yim1, Hun-Kuk Park1 and Joo-Ho Chung1 1Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, Seoul, Korea 2Department of Internal Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea 4Department of Orthopedic Surgery, College of Medicine, Kyung Hee University, Seoul, Korea * Contributed equally Corresponding author: Joo-Ho Chung, jhchung@khu.ac.kr Received: 19 Feb 2004 Revisions requested: 5 Apr 2004 Revisions received: 26 May 2004 Accepted: 8 Jun 2004 Published: 19 Jul 2004 Arthritis Res Ther 2004, 6:R415-R421 (DOI 10.1186/ar1207) /content/6/5/R415 ? 2004 Jin et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Estrogen and estrogen receptors (ERs) are known to play important roles in the pathophysiology of osteoarthritis (OA). To investigate ER-α gene polymorphisms for its associations with primary knee OA, we conducted a case–control association study in patients with primary knee OA (n = 151) and healthy individuals (n = 397) in the Korean population. Haplotyping analysis was used to determine the relationship between three polymorphisms in the ER-α gene (intron 1 T/C, intron 1 A/G and exon 8 G/A) and primary knee OA. Genotypes of the ER-α gene polymorphism were determined by PCR followed by restriction enzyme dig