Evaluation of tissue perfusion parameters and intravascular volume, emphasizing the inferior vena cava diameter and collapsibility.docVIP

Evaluation of tissue perfusion parameters and intravascular volume, emphasizing the inferior vena cava diameter and collapsibility.doc

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Evaluation of tissue perfusion parameters and intravascular volume, emphasizing the inferior vena cava diameter and collapsibility

Available online /supplements/11/S3 Critical Care Volume 11 Suppl 3, 2007 Fourth International Symposium on Intensive Care and Emergency Medicine for Latin America S?o Paulo, Brazil, 20–23 June 2007 Published online: 19 June 2007 These abstracts are online at /supplements/11/S3 ? 2007 BioMed Central Ltd Basic science Reference 1. Janiszewski M, Do Carmo AO, Pedro MA, et al.: Crit Care Med 2004, 32:818-825. P1 P2 Platelet-derived exosomes are redox signaling particles Which is the worst factor in sepsis aggravation: translocated bacterial amount or gut-associated lymphoid tissue activation? MH Gambim1, AO Carmo2, L Marti2, S Veríssimo-Filho1, LR Lopes1, M Janiszewski1,2 1Faculdade de Medicina and Instituto de Ciências Biomédicas, University of S?o Paulo – SP, Brazil; 2Instituto Israelita de Ensino e IHJ Koh1, JL Menchaca-Diaz2, AMA Liberatore2, MY Taki1, U Fagundes-Neto2, J Francisco Jr1 Pesquisa, Albert Einstein Hospital, S?o Paulo – SP, Brazil Critical Care 2007, 11(Suppl 3):P1 (doi: 10.1186/cc5788) 1Department of Surgery and 2Department of Pediatrics, Federal University of S?o Paulo – SP, Brazil Critical Care 2007, 11(Suppl 3):P2 (doi: 10.1186/cc5789) Sepsis, the body’s response to infection, is associated with extremely high mortality rates. Why a protective mechanism turns into a deadly clinical picture is a matter of debate, and goes largely unexplained. In previous work we demonstrated that platelet-derived microparticles (MP) can induce endothelial and vascular smooth muscle cell apoptosis in septic patients through NADPH oxidase- dependent superoxide release [1]. In this work we sought to create a model for ex vivo generation of septic-like MP and to identify the pathways responsible for MP free radical release and effects. Septic shock is a condition related to the generation of high amounts of thrombin, TNFα and nitrogen reactive species. Human Introduction The intestinal hypothesis of se

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