Evaluation of tissue perfusion parameters and intravascular volume, emphasizing the inferior vena cava diameter and collapsibility.docVIP
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Evaluation of tissue perfusion parameters and intravascular volume, emphasizing the inferior vena cava diameter and collapsibility
Available online /supplements/11/S3
Critical Care Volume 11 Suppl 3, 2007
Fourth International Symposium on Intensive Care and
Emergency Medicine for Latin America
S?o Paulo, Brazil, 20–23 June 2007
Published online: 19 June 2007
These abstracts are online at /supplements/11/S3
? 2007 BioMed Central Ltd
Basic science
Reference
1.
Janiszewski M, Do Carmo AO, Pedro MA, et al.: Crit Care Med
2004, 32:818-825.
P1
P2
Platelet-derived exosomes are redox signaling particles
Which is the worst factor in sepsis aggravation: translocated
bacterial amount or gut-associated lymphoid tissue
activation?
MH Gambim1, AO Carmo2, L Marti2, S Veríssimo-Filho1,
LR Lopes1, M Janiszewski1,2
1Faculdade de Medicina and Instituto de Ciências Biomédicas,
University of S?o Paulo – SP, Brazil; 2Instituto Israelita de Ensino e
IHJ Koh1, JL Menchaca-Diaz2, AMA Liberatore2, MY Taki1,
U Fagundes-Neto2, J Francisco Jr1
Pesquisa, Albert Einstein Hospital, S?o Paulo – SP, Brazil
Critical Care 2007, 11(Suppl 3):P1 (doi: 10.1186/cc5788)
1Department of Surgery and 2Department of Pediatrics, Federal
University of S?o Paulo – SP, Brazil
Critical Care 2007, 11(Suppl 3):P2 (doi: 10.1186/cc5789)
Sepsis, the body’s response to infection, is associated with
extremely high mortality rates. Why a protective mechanism turns
into a deadly clinical picture is a matter of debate, and goes largely
unexplained. In previous work we demonstrated that platelet-derived
microparticles (MP) can induce endothelial and vascular smooth
muscle cell apoptosis in septic patients through NADPH oxidase-
dependent superoxide release [1]. In this work we sought to create
a model for ex vivo generation of septic-like MP and to identify the
pathways responsible for MP free radical release and effects.
Septic shock is a condition related to the generation of high
amounts of thrombin, TNFα and nitrogen reactive species. Human
Introduction
The intestinal hypothesis of se
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