Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection.docVIP

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Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection.doc

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Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection

Viruses 2012, 4, 924-939; doi:10.3390/v4060924 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection Nélida V. Gómez 1,2,*, Adriana Fontanals 4,5, Víctor Castillo 2, María A. Gisbert 2, Adriana Suraniti 1,2, Graciela Mira 3 and Paola B. Pisano 2 1 Service of Electrophysiology, Veterinary Medicine Teaching Hospital of the University of Buenos Aires, San Martín Av. 4453, CP 1427, Buenos Aires, Argentina; E-Mail: asuraniti@fvet.uba.ar 2 Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina; E-Mails: clinpeq@fvet.uba.ar; gisbertma@; paolabpisano@ 3 Department of Clinical Pathology. School of Veterinary Sciences, University of Buenos Aires, Buenos Aires, 1427, Argentina; E-Mail: gmira@fvet.uba.ar 4 Department of Immunology, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina; E-Mail: afontanals@fvet.uba.ar 5 Pablo Cassará Laboratory, Saladillo 2452, Buenos Aires, Argentina * Author to whom correspondence should be addressed; E-Mail: ngomez@fvet.uba.ar; Tel.: +5411-4503-6976; Fax: +5411-4-5248496. Received: 1 May 2012; in revised form: 14 May 2012 / Accepted: 24 May 2012 / Published: 30 May 2012 Abstract: The aim of this study was to evaluate the efficacy of the antiretrovirals: Zidovudine (ZDV) alone; ZDV + Recombinant Human Interferon-α (rHuIFN-α); ZDV + Lamivudine (3TC) and ZDV + valproic acid (Valp) on naturally feline immunodeficiency virus (FIV)-infected cats, in the late phase of the asymptomatic stage of infection. The follow-up was performed over one year, through clinical evaluation and the determination of viral loads and CD4+/CD8+ ratios. Neurological signs were studied by visual a