Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication).docVIP

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Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication).doc

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Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication)

Genet.Sel.Evol.40(2008)639–661 óINRA,EDPSciences,2008 DOI: Availableonlineat: Originalarticle Evolutionofthepolymorphismatmolecular markersinQTLandnon-QTLregions inselectedchickenlines (OpenAccesspublication) Vale′rie LOYWYCK1*,BertrandBED’HOM1, Marie-He′le`ne PINARD-VAN DER LAAN1,Fre′de′rique PITEL2, Etienne′ VERRIER1,PiterBIJMA3 1Ge′ne′tique etDiversite′ AnimalesUMR1236,INRA/AgroParisTech, 78352Jouy-en-Josas,France 2Ge′ne′tique CellulaireUR444,INRA,31326Castanet-Tolosan,France 3AnimalBreedingandGenomicsGroup,WageningenUniversity,6700AHWageningen, TheNetherlands (Received22October2007;accepted18June2008) Abstract–Weinvestigatedthejointevolutionofneutralandselectedgenomicregionsin threechickenlinesselectedforimmuneresponseandinonecontrolline.Wecomparedthe evolution of polymorphism of 21 supposedly neutral microsatellite markers versus 30microsatellitemarkerslocatedinsevenquantitativetraitloci(QTL)regions.Divergence oflineswasobservedbyfactoranalysis.Fivesupposedlyneutralmarkersand12markersin theQTLregionsshowedFstvaluesgreaterthan0.15.However,thenon-signi?cantdifference (P0.05)betweenmatricesofgeneticdistancesbasedongenotypesatsupposedlyneutral markersontheonehand,andatmarkersinQTLregions,ontheotherhand,showedthat noneofthemarkersintheQTLregionswerein?uencedbyselection.Asupposedlyneutral marker and a marker located in the QTL region on chromosome 14 showed temporal variationsinallelefrequenciesthatcouldnotbeexplainedbydriftonly.Finally,tocon?rm thatmarkerslocatedinQTLregionsonchromosomes1,7and14wereunderthein?uenceof selection,simulationswereperformedusinghaplotypedroppingalongtheexistingpedigree. Inthezonelocatedonchromosome14,thesimulationresultscon?rmedthatselectionhadan effectontheevolutionofpolymorphismofmarkerswithinthezone. selection/quantitativetraitloci/hitchhiking/chicken/geneticdiversity 1. INTRODUCTION Thereiscurrentlyalargeinterestincharacterisingvariationpatternsinorder to identify regions of the genome that are under selection. For that purpose,