Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases.docVIP

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Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases.doc

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Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases

Molecules 2012, 17, 2955-2967; doi: 10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases Guo-Ying Zuo 1,*, Xin-Juan Zhang 1,2,?, Cui-Xian Yang 1,3,?, Jun Han 3, Gen-Chun Wang 1 and Zhong-Qi Bian 4,* 1 Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China; E-Mails: shmily_zxj2008@163.com (X.-J.Z.); ycx484@126.com (C.-X.Y.); kmwgc12@126.com (G.-C.W.) 2 Kunming Medical College, Kunming 650032, China 3 Yunnan Traditional Chinese Medical College, Kunming 650500, China; E-Mail: hanzjn@126.com 4 Center for Infectious Diseases, Kunming General Hospital, PLA, Kunming 650032, China ? These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: zuoguoying@263.net (G.-Y.Z.); bzq@ (Z.-Q.B.); Tel./Fax: +86-871-477-4941 (G.-Y.Z.). Received: 8 February 2012; in revised form: 27 February 2012 / Accepted: 29 February 2012 / Published: 9 March 2012 Abstract: The in vitro antimicrobial activities of 30 Chinese medicinal plants were evaluated with reference to the treatment record of infectious diseases in the Traditional Chinese Medicine (TCM) literature. The plant materials were extracted with 80% ethanol and the extracts were primarily screened against conventional clinical pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans by the agar diffusion method. Their inhibition zone diameters (IZDs, mm, 50 mg/mL) ranged from 8 to 24. The 21 extracts which showed IZDs ≥10 mm against MSSA were also active against methicillin-resistant S. aureus (MRSA) with lower IZDs of 9.0–18.8 mm. They were further subjected to minimal inhibitory concentration and minimal bactericidal concentration (MIC/MBC, μG/mL) assays, which were 8