Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells.docVIP

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Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells.doc

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Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells

Available online /content/11/5/R137 Research article Open Access Vol 11 No 5 Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells Christine L Le Maitre1,2, Anthony J Freemont2 and Judith A Hoyland2 1Biomedical Research Centre, Biosciences, Faculty of Health and Wellbeing, Sheffield Hallam University, City Campus, Owen Building, Howard Street, Sheffield, S1 1WB, UK 2Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK Corresponding author: Judith A Hoyland, judith.hoyland@manchester.ac.uk Received: 26 Mar 2009 Revisions requested: 15 May 2009 Revisions received: 30 Jul 2009 Accepted: 15 Sep 2009 Published: 15 Sep 2009 Arthritis Research Therapy 2009, 11:R137 (doi:10.1186/ar2808) This article is online at: /content/11/5/R137 ? 2009 Le Maitre et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Loss of intervertebral disc (IVD) matrix and ultimately disc height as a result of degeneration has been implicated as a major cause of low back pain (LBP). The use of anabolic growth factors as therapies to regenerate IVD matrix, hence restoring disc height and thus reversing degenerative aggrecan and type II collagen gene expression and proteoglycan synthesis in nucleus pulposus (NP) cells derived from degenerate IVDs. Results We demonstrated that CDMP 1 and 2 were expressed in the non-degenerate and degenerate IVD, particularly in cells of the NP. A small decrease in the number of CDMP 1 and 2 immunopositive cells was seen with deg