Factors associated with the success of rabies vaccination of dogs in Sweden.docVIP

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Factors associated with the success of rabies vaccination of dogs in Sweden.doc

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Factors associated with the success of rabies vaccination of dogs in Sweden

Berndtssonetal.ActaVeterinariaScandinavica2011,53:22 /content/53/1/22 RESEARCH OpenAccess Factorsassociatedwiththesuccessofrabies vaccinationofdogsinSweden LouiseTBerndtsson*?,Ann-KristinJNyman?,EstebanRivera,BerndtKlingeborn? Abstract Background:UnitedKingdom,Ireland,MaltaandSwedenmaintaintheirnationalprovisionsforatransitional periodregardingrulesconcerningrabiesvaccinationandindividualserologicaltestforrabiesneutralizing antibodies.Thepurposeofvaccinatingdogsagainstrabiesistoestablishpre-exposureimmunityandprotect individualanimalsfromcontractingrabies. Theaimofthestudywastoinvestigatefactorsassociatedwithreachingtheinternationallyacceptedthreshold antibodytitreof0.5IU/mLafterrabiesvaccinationofdogs. Methods:Thestudywasaprospectivesinglecohortstudyincluding6,789samplesfromSwedishdogsvaccinated withcommerciallyavailablevaccinesinSweden,andthedog’santibodyresponsesweredeterminedbytheOIE approvedFAVNtest.Informationonpotentialriskfactors;breed,age,gender,dateofvaccination,vaccinelabeland thenumberofvaccinations,wascollectedforeachdog.Associationsbetweenthedependentvariable,serological response≥0.5IU/mLor0.5IU/mLandeachofthepotentialriskfactorswereinvestigatedusinglogistic regressionanalysis. Results:Of6,789vaccinateddogs,6,241(91.9%)hadanapprovedtestresultof≥0.5IU/mL.Theresultsofthe multivariablelogisticregressionanalysisshowedthatvaccinatingwithvaccineBreducedtheriskofhaving antibodytitresof0.5IU/mLby0.2timescomparedwithvaccinationusingvaccineA.Breedsizewasfound significantasaninteractionwithnumberofvaccinationsandageatvaccinationasaninteractionwithdayof antibodytestingafterlastvaccination.Insummary,largerbreedswereathigherriskofhavingantibodytitresof 0.5IU/mLbutifvaccinatedtwicethisriskwasreduced.Moreover,therewereaincreasedriskfordogs 6monthsofageand5yearsofagetohaveantibodytitresof0.5IU/mL,butthiswasaffectedbynumber ofdaysfromvaccinationtilltesting. Conclusions:Theprobabilityofsuccessofrabiesvaccinationsofdogsdependsontypeofvaccineused,numberof rabiesvaccinati