Extraskeletal myxoid chondrosarcoma in the lung asymptomatic lung mass with severe anemia.docVIP

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Extraskeletal myxoid chondrosarcoma in the lung asymptomatic lung mass with severe anemia.doc

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Extraskeletal myxoid chondrosarcoma in the lung asymptomatic lung mass with severe anemia

Zhouetal.DiagnosticPathology2012,7:112 /content/7/1/112 CASE REPORT OpenAccess Extraskeletalmyxoidchondrosarcomainthelung: asymptomaticlungmasswithsevereanemia QianjunZhou1,5*,GuangzhongLu2,AiqunLiu3andTadasuKohno4 Abstract Extraskeletalmyxoidchondrosarcoma(EMC)isararesoft-tissuesarcoma,whichprimarilyoccursdeepinthe extremities,especiallyinskeletalmuscle,ortendon.EMCofthepleurahasbeendescribed,however,nocaseof primaryEMCarisingfromlunghasbeenpreviouslyreported.Wedescribeherein,a51-year-oldAsianfemaleinitially manifestedwithsignsofsevereanemiawhopresentedwithalungmassunrelatedtopleurathatwas morphologicallytypicalEMC,withstrongimmunoreactivityforvimentinandNSE.Twoweeksafterresection,the anemiawascured.Thepatientcontinuedwithfollow-up,withoutsignofabnormality32monthsafteroperation. Virtualslides:Thevirtualslidesforthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/vs/ 2882199847396682 Keywords:Extraskeletalmyxoidchondrosarcoma,Lung,Immunohistochemistry,Anemia Background butfailedtofindanymassesinthesofttissueofextrem- Extraskeletal myxoid chondrosarcoma (EMC) was first ities or pelvis through palpation. A computed tomog- reported by Enzinger and Shiraki in 1972 as a rare raphy (CT) scan disclosed a 41×33 mm parenchymal soft-tissue sarcoma, which primarily occurs deep in the mass on apico-posterior segment of left upper lobe, CT extremities, especially in skeletal muscle, or tendon [1]. value was 26 Hounsfield unit (HU). The patient had a Unusual locations include tongue, retroperitoneum, 10-year history of left lung nodule by chest x-ray, how- spine, intracranium, testis, inguinal region, synovium, ever,nofilmswereavailablecurrently.Wholebloodcell mammary gland, and labium. count was characterized as microcytic hypochromic We report the clinicopathological features of a female anemia, with RBC 2.67×1012/L, Hb 54 g/L. Serum iron patient with EMC of the lung initially manifested with was 2.2 μmol/L, total iron binding capacity 74 μmol/L. as