Expression of CD147 on monocytesmacrophages in rheumatoid arthritis its potential role in monocyte accumulation and matrix metalloproteinase production.docVIP

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Expression of CD147 on monocytesmacrophages in rheumatoid arthritis its potential role in monocyte accumulation and matrix metalloproteinase production.doc

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Expression of CD147 on monocytesmacrophages in rheumatoid arthritis its potential role in monocyte accumulation and matrix metalloproteinase production

Available online /content/7/5/R1023 Research article Open Access Vol 7 No 5 Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production Ping Zhu1, Jin Ding1, Jun Zhou2, Wei-Jia Dong1, Chun-Mei Fan1 and Zhi-Nan Chen2 1Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xian, Shaanxi Province, China 2Department of Cell Biology, Fourth Military Medical University, Xian, Shaanxi Province, China Corresponding author: Zhi-Nan Chen, chcerc2@ Received: 5 Feb 2005 Revisions requested: 15 Mar 2005 Revisions received: 9 May 2005 Accepted: 31 May 2005 Published: 23 Jun 2005 Arthritis Research Therapy 2005, 7:R1023-R1033 (DOI 10.1186/ar1778) This article is online at: /content/7/5/R1023 ? 2005 Zhu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Monocytes/macrophages play an important role in rheumatoid arthritis (RA) pathogenesis. They can activate fibroblasts through many molecules, including IL-1 and tumor necrosis factor-alpha, but there have been very few reports on the role of CD147 in RA. In our study, the results of flow cytometry reveal that the mean fluorescence intensity (MFI) of CD147 expression on CD14+ monocytes of peripheral blood from RA patients was higher than that in normal control and ankylosing spondylitis (AS) patients. The MFI of CD147 expression on the CD14+ monocytes in RA synovial fluid was higher than that in RA peripheral blood. Immunohistochemical staining shows that CD147 expression in RA synovium correlated with matrix mononuclear cells. The role of CD147 in MMP production and cell invasion in vitro were studied