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Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy.doc

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Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy

Available online /content/12/6/R163 Research Open Access Vol 12 No 6 Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy Luigi Camporota, Eleonora Corno, Eleonora Menaldo, John Smith, Katie Lei, Richard Beale and Duncan Wyncoll Adult Intensive Care Unit, Guys and St Thomas NHS Foundation Trust, St Thomas Hospital, 1st Floor East Wing, Lambeth Palace Road. London SE1 7EH, UK Corresponding author: Duncan Wyncoll, duncan.wyncoll@gstt.nhs.uk Received: 10 Sep 2008 Revisions requested: 14 Oct 2008 Revisions received: 10 Nov 2008 Accepted: 18 Dec 2008 Published: 18 Dec 2008 Critical Care 2008, 12:R163 (doi:10.1186/cc7163) This article is online at: /content/12/6/R163 ? 2008 Camporota et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Drotrecogin alfa (activated) (DrotAA) is licensed in the United States and the European Union for the treatment of severe sepsis with multiple organ failure. Patients with severe sepsis on renal replacement therapy (RRT), who typically receive additional anticoagulation to prevent circuit clotting, may be at higher risk of bleeding when DrotAA is administered in addition to standard anticoagulation. However, the effects of DrotAA on filter duration in the absence of additional anticoagulation have not been established. The aim of this study was to analyse the filter survival time (FST), and to quantify the requirement of packed red cells (PRC) and blood products during DrotAA infusion. standard anticoagulation after the DrotAA infusion had been completed (post-DrotAA). Results The proportion of filter changes due to