结构生物学sturcture biology explore-40.pdfVIP

409 Did evolution leap to create the protein universe? Burkhard Rost The genomes of over 60 organisms from all three kingdoms of Although most of these analyses utilize a wealth of biological life are now entirely sequenced. In many respects, the inventory data, they are not explicitly based on the fact that we have of proteins used in different kingdoms appears surprisingly entire genome sequences from representatives of all three similar. However, eukaryotes differ from other kingdoms in that kingdoms of life: eukarya, bacteria (prokaryotes) and they use many long proteins, and have more proteins with archaea. What do we learn from generating lists of parts of coiled-coil helices and with regions abundant in regular the whole [10,11•]? secondary structure. Particular structural domains are used in many pathways. Nevertheless, one domain tends to occur only Here, I focus on findings from methods that endeavor to once in one particular pathway. Many proteins do not have capture overall features for entire organisms. I challenge close homologues in different species (orphans) and there the assumption that bioinformatics is slowly but steadily could even be folds that are specific to one species. This view approaching the point at which we can smoothly move implies that protein fold space is discrete. An alternative model through neighborhoods of protein relationships in order to suggests that structure space is continuous and that modern generate an atlas of the fates and functions of proteins in proteins evolved by aggregating fragments of ancient proteins. the context of the cell. Either way, after