抗癫痫药遗传药理学研究进展课件.pptVIP

抗癫痫药遗传药理学研究进展 Differential drug efficacy Polymorphisms Affect Drug Handling and Drug Targets Drug transporters Drug metabolism CYP2C9/19 genotypes,the daily doses and serum concentrations of phenytoin in 134 patients with epilepsy End-organ targets Immunogenetic background Carbamazepine-induced Stevens Johnson Syndrome (SJS) and HLA-B*1502 Pharmacogenetics and Genomics 2006, 16:297–306 Same symptoms Same findings Same disease (?) Same Drug…. Different Effects ? Genetic Differences Possible Reasons: Non-Compliance… Drug-drug interactions…