HIV特性(国外英文资料).doc

HIV特性 HIV features. TXT HIV features: Lymphocytic, neurotropic The main infection is CD4 + T lymphocytes Heat sensitive, not sensitive to the 0.1% formalin and ultraviolet light Neutralizing antibodies are rare, and the serum is still infectious when the antibodies and viruses coexist AIDS infection: The infectious agent and the asymptomatic virus carrier, blood, sperm, uterus and vaginal secretions Transmission path 1. Sexual contact with gay and straight 2. Injection 3. The mother-to-child transmission (PMTCT) 4. The other way High-risk groups of gay men, promiscuous sex, intravenous drug addicts, hemophilia and multiple donors, under 50 years of age Diagnosis and differential diagnosis of AIDS: Risk factors for acute infection and the performance of similar serum diseases The risk of severe opportunistic infections or tumors in high-risk groups of chronic infectious diseases, the CD4 / CD8 ratio inversion There are two or two people at high risk who should consider HIV/AIDS The weight has dropped by more than 10% recently Chronic cough or diarrhea for more than one month Intermittent or persistent fever for more than one month Swollen lymph nodes all over the body Recurrent herpes zoster or chronic disseminated herpes simplex infection Oral candida infection Laboratory diagnosis: Hiv-1 antibody tests: p24 antibody and gpl20 antibody two times ELISA positive, then immune-printing (WB) and solid-phase radioimmunoprecipitate (SRIP) Antigen test: ELISA method for p24 antigen HIV RNA: quantitative PCR or branched DNA analysis for HIV quantification, diagnosis, evaluation of prognosis and efficacy The differential diagnosis Idiopathic CD4 + T lymphocyte reduction: foreign minority of CD4 + T lymphocytes are significantly reduced and patients with severe opportunistic infections are not infected with hiv-1 or hiv-2. Identification is mainly dependent on hiv-1 and hiv-2 etiology Secondary CD4 + T lymphocyte reduction: mainly in tumors and autoimmune diseases Lung TB is i