盐酸米多君片(国外英文资料).docVIP

盐酸米多君片 Midodrine hydrochloride (midodrine hydrochloride Tablets) (methoxyamine flynx tablet, tube pass) (plus or minus) - 2-amino-n - [2, 5-dimethoxybenzene] -dimethylethyl] acetamide 【 properties 】 [pharmacological toxicology] The drug of this product is inactive. After oral administration, transamination of aminoacetic acid in the blood was converted into active metabolite deglycine. In addition to the selective peripheral sympathizer a1, which is an exciting agent, it ACTS directly on the postsynaptic and releases the nephrotonic stimulant. Regulating function, this product has the blood vessel tone in patients with orthostatic dysregulation of blood pressure can increase peripheral resistance, vein, blood sedimentation, it can prevent the lower limb blood backflow, keep blood volume stability, upright position so as to improve patients caused by blood pressure, improve circulation capacity lack of symptoms (such as the depressed since morning, fatigue, dizziness, vertigo, etc.). This article does not cause the central nervous system to increase arousal, but it does not have a direct effect on the heart, but the heart rate may decline because of the feedback. Foreign sources report that midol can raise blood pressure and improve the accompanying conditions such as weakness, syncope, blurred vision and fatigue. 1) controlled clinical study: two randomized crossover design, double-blind controlled study application research midodrine compared with placebo, midodrine (ephedrine or fludrocortisone) and controlled drug curative effect. In the study of the main curative effect evaluation standard for the increase of blood pressure and no syncope or syncope before symptoms and blood pressure increase and compared with fludrocortisone comprehensive clinical curative effect. Placebo-controlled studies show that midodrine obviously improve the patients upright ability and establish a blood pressure, cant stand before treatment patients was 10.7%, after midodrine treatment