肠易激综合症(国外英文资料).docVIP

肠易激综合症 Irritable bowel syndrome (IBS) An important overview define As early as 1993 there is a more authoritative definition: IBS is a kind of organic gastrointestinal function disorder, due to the role of genetic and psychological factors, lead to the susceptibility of gastrointestinal function, abnormal gastrointestinal movement, high visceral sensitivity and the changes of mucosal immune, performance patients was related to defecate or changes in bowel habit of abdominal pain or discomfort, and has the characteristic of bowel disorders. incidence Chinese and foreign scholars have estimated that 10-20% of adults and adolescents in the global population have symptoms of IBS, and women generally outnumber men. Symptoms often occur repeatedly, about two-thirds of the patients with other FGID symptomatic overlap, can seriously affect the quality of life of patients with IBS, resulting in a large number of medical expenses, is the most typical psychosomatic disease in FGID. The cause and mechanism of Common cause is the result of the interaction between the bodys stress response and psychological factors, different individuals may be related to genetic, environmental, psychological, social, and gastrointestinal infection factors, lead to a high sensitive to changes in gastrointestinal, liver, brain gut axis interaction disorders, autonomic nervous and hormonal changes, etc., accompanied by mental disorders (e.g., panic, anxiety, post-traumatic stress disorder, etc.), patients with sleep disorder and coping, stressful life events often can lead to symptoms worsen, but now with the psychological factors and the exact relationship between IBS is not very clear. In recent years, the study found that a third of IBS patients have a history of gastrointestinal tract infection, emphasize the spirit of psychological factors on the pathogenesis of IBS at home and abroad, pay more attention to the nerve peptide receptors and related functional role in the pathogenesis of IBS. In