咖啡因体内代谢及其应用的研究进展_陈尧.pdfVIP

# 256# 2010 41 4 * 陈 尧 周宏灏v (, 4 10078) 咖啡因是从茶叶咖啡果中提取出来的一种生物碱, 常用于治疗神经衰弱和昏迷 苏咖啡 因体内代谢过程 杂, 现已发现咖啡因的 15种代谢产物, 参与代谢过程的酶类也被逐 一证实尿 液咖啡因代谢产物比率(UCMRs) 常用于多种药物代谢酶活性的评估, 主要包括 CYP1A2CYP2A 6 N-乙酰转移酶和黄嘌呤氧化酶, 咖啡因及其代谢产物检测方法也逐步得到改进与更新总之, 咖啡 因与人类健康密切相关, 以及其重要的科研应用价值, 一直受到普遍关注 咖啡因; 药物代谢; 代谢酶 R969 Progress in the Research of C affeine M etabolism and Its App lication in V ivo CHEN Y ao, ZHOU H on -Hao ( Institu te of C lin ical Pharm aco logy, Central South Un iversity, Chan sha 410078, Ch ina) A bstract Caffeine, a k ind of alkaloid, extracted from tea and coffee fruit, is common ly used in the treatment of neurasthen ia and for com a recovery. The metabolic process of caffeine in vivo is complex. F ifteen k inds ofmetabolites have been found, and the enzymes involved in the metabolic processes have also been confirmed. The urinary caffeinem etabolites ratios are commonly used in the assessm ent of ac- tivities of dru metabolizin enzymes, main ly includin CYP 1A2, CYP2A 6, N-acetyltransferase and xan- thine ox idase. M ethods for detection of caffeine and itsm etabolites have been mi proved steeply. In brief, caffeine has been paid close attention due to its in tmi ate connection w ith hum an health as w ell as its mi - portance in application in scien tific research. K ey words caffeine; dru m etabolism; metabolic enzym es [ 2] ( caffeine) , , C H 8 10 N O , 1, 3, 7- 3, 7--1, , 15~ 60, 4 2 [ 1] 120, 3, 7-1H--2, 6- ,