白芍的化学成分研究和分析英文文献SCI 系列5.pdf

Journal of Ethnopharmacology 141 (2012) 701–708 Contents lists available at SciVerse ScienceDirect Journal of Ethnopharmacology j o u rn al h omepage: w w w. elsev /locate/jethpharm Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine Yan Fang Fan a,b , Ying Xie b , Liang Liu b,c , Hing Man Ho b , Yuen Fan Wong b , Zhong Qiu Liu a,∗ , Hua Zhou b,c,∗∗ a Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China b Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China c State Key Laboratory for Quality Research of Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, PR China a r t i c l e i n f o a b s t r a c t Article history: Ethnopharmacological relevance: To investigate the influence of paeoniflorin (major bioactive component Received 30 April 2011 of Paeonia lactiflora Pall.) on the pharmacokinetic behavior of aconitine (major toxic and bioactive compo- Received in revised form 30 August 2011 nent ofAconitum carmichaeli Debx.) and potential detoxifying effect of paeoniflorin on the acute toxicity of Accepted 2 September 2011 aconitine, which may provide in depth understanding to the toxicity reduction effect of Paeonia lactiflora Available online 10 September 2011 to Aconitum carmichaeli . Mater