纳米二氧化钛神经毒性及其机制的研究进展.PDF

纳米二氧化钛神经毒性及其机制的研究进展  周婕 a b a* ，王文浩 ，刘素鹏 (宜春学院，a.医学院，b.生命科学与资源环境学院，江西 宜春 336000) 摘要：纳米二氧化钛(TiO2 NPs)作为一种新型纳米材料，已成为多个领域的研究热点。随着在日常生活中接触 TiO2 NPs 愈发容易，TiO NPs 的毒性也逐渐受到关注。TiO NPs 能够通过血脑屏障进入脑内并蓄积，引起脑组织、神经细胞的损 2 2 伤，影响情感与认知，降低学习记忆能力。本文对近年来 TiO2 NPs 引起的体内外神经毒性，以及其毒性机制如氧化应激、 炎症反应、凋亡等的研究现状进行综述，旨在丰富 TiO2 NPs 的毒性研究数据库，为其日常安全使用提供科学依据。 关键词：纳米二氧化钛；神经毒性；炎症；氧化应激；凋亡 中图分类号：R961 文献标志码：A 文章编号：1007-7693(2017)05-0771-06 DOI: 10.13748/ki.issn1007-7693.2017.05.033 引用本文：周婕, 王文浩, 刘素鹏. 纳米二氧化钛神经毒性及其机制的研究进展[J]. 中国现代应用药学, 2017, 34(5): 771-776. Toxicity of Titanium Dioxide Nanoparticles in Central Nervous System and the Molecular Mechanisms Involved a b a* ZHOU Jie , WANG Wenhao , LIU Supeng (Yichun University, a.School of Medicine, b.School of Life Science and Environmental Resource, Yichun 336000, China) ABSTRACT: Titanium dioxide nanoparticles(TiO2 NPs) possess unique characteristics and have found many practical applications in industry and daily life. A wide use of TiO2 NPs raises the question about their safety to the environment, humans and biota. Once exposed to TiO2 NPs, they could be absorbed and easily enter the body, cross blood-brain barrier and then accumulated in the brain regions, especially in the cortex and hippocampus, leading to dysfunctions of central nerve system. In vivo and in vitro studies have demonstrated that the morphology and function of glial or neuronal cells could be damaged by TiO2 NPs. It is summarized the previous studies that the neurotoxic mechanisms mainly consist of oxidative stress, inflammation, apoptosis, genotoxicity, and autophagy. Meanwhile,