异甘草酸镁、还原型谷胱甘肽在预防肝癌血管栓塞术后肝损害的对比研究.docVIP

异甘草酸镁、还原型谷胱甘肽在预防肝癌血管栓塞术后肝损害的对比研究 　　摘要： 目的 ：对比异甘草酸镁、还原型谷胱甘肽两种药物在预防肝癌血管栓塞术后肝损害的效果。方法： 选择在我科住院的原发性肝癌病人95例为研究对象，根据入院时间单双日分为两组，A组61例使用还原型谷胱甘肽、B组34例使用异甘草酸镁进行预防。观察指标 术前、术后3天两组病例肝功能的对比。结果： 两组术前总胆红素对比有显著差异（P=0.0494），白蛋白对比有显著差异（P=0.4251），谷丙转氨酶对比无显著差异（P=0. 5644），谷草转氨酶对比有显著差异（P=0. 2120），凝血酶原时间对比无显著差异（P=0. 9772）；两组术后总胆红素对比有显著差异（P=0.0205），白蛋白对比有显著差异（P=0.2502），谷丙转氨酶对比有显著差异（P=0. 0195），谷草转氨酶对比有显著差异（P=0. 0062），凝血酶原时间对比无显著差异（P=0. 5105）。结论： 异甘草酸镁在预防肝癌血管栓塞术后肝损害的效果稍优于还原型谷胱甘肽 关键词： 异甘草酸镁 还原型谷胱甘肽 肝癌血管栓塞术 肝功能 预防 Abstract： objective to compare different magnesium glycyrrhizic acid and reduced glutathione two drugs in the prevention of liver cancer vascular embolization of postoperative liver damage effect. Methods 95 cases with primary liver cancer patients hospitalized in our department as the research object， according to admission time ChanShuangRi divided into two groups， A group of 61 cases with reduced glutathione， B group of 34 cases using different glycyrrhizic acid magnesium for prevention. Observation indexes of preoperative and postoperative 3 days two groups of cases of liver function. Results two groups of preoperative total bilirubin compared with significant difference （P = 0.0494）， albumin contrast significant differences （P = 0.4251）， alanine aminotransferase compared to no significant difference （P = 0. 5644）， aspertate aminotransferase compared with significant difference （P = 0. 2120）， prothrombin time compared with no significant difference （P = 0. 9772）； Two groups of postoperative total bilirubin compared with significant difference （P = 0.0205）， albumin contrast significant differences （P = 0.2502）， alanine aminotransferase compared with significant difference （P = 0. 0195）， aspertate aminotransferase compared with significant difference （P = 0. 0062）， prothrombin time compared with no significant difference （P = 0. 5105）. Conclusion different glycyrrhizic acid magnesium in preventing postoperative liver damage liver vascular embolism was slightly better than the