531例患者泌尿生殖道支原体感染及药敏情况分析.docVIP

531例患者泌尿生殖道支原体感染及药敏情况分析 　　作者：向华国　　作者单位：深圳市福永医院,广东 深圳 518103 　　【摘要】 目的：探讨解脲支原体(UU)和人型支原体(MH)在性病门诊患者中感染及耐药情况,为临床合理用药以及控制脲路感染提供依据。方法：采用上海奥普生物医药有限公司生产的支原体培养鉴定药敏试剂盒,对531例非淋菌性尿道炎(nongonococcal urethritis, NGU) 患者分泌物进行检测。结果：531例NGU患者，支原体阳性125例，感染率为23.5%，其中单纯UU阳性83例，占15.6%，单纯MH阳性6例，占1.1%,UU+MH阳性36例，占6.8%，UU、MH总检出率分别是22.4%、7.9%。女性的感染率高于男性(P0.01)。UU、MH、UU+MH对强力霉素、交沙霉素、美满霉素较为敏感。对于MH和UU混合感染者，各种药物的体外敏感性显著降低。结论：泌尿生殖道支原体感染以UU为主，UU、MH、UU+MH的耐药率存在一定的差异。药物治疗支原体以强力霉素、交沙霉素最好、其次是美满霉素。 　　【关键词】 支原体 药物耐药性 泌尿生殖道感染 药敏实验 　　The Study on Mycoplasma Urogenital Infection and Drug Resistance in 531 Patients 　　XIANG Huaguo,MAO Lugui,LIU Jingguang,HE Dayuan,LIU Dianlang 　　(Fuyong Hospital of Shenzhen,Shenzhen,Guangdong 518103,China;Medical College of Hunan Normal University,Changsha,Hunan 410006,China) 　　Abstract: Objective To investigate the drug resistance and infection ratio of UU and MH for the STD patients, and provide the data for effective therapy and control to mycoplasma infection. Methods The mycoplasmas culture and antibiotic susceptivity reagent made by Shanghai Aopu biomedical limted corp were used to detect the secretion of the NGU patientsurethra and genitalia. Results The positive rate of mycoplasma was 23.5%,83(15.6%)NGU patients were detected only UU; 6(1.1%)NGU patients were detected only MH; 36(6.8%)NGU patients were detected both UU and MH; Total detection ratio of UU and MH is respectively 22.4% and 7.9%. Infection rate of female patients were distinctly higher than male (P0.01). UU，MH and UU+MH were susceptive to Doxycycline, Josamycin and Minocycline.The susceptibilities in vitro of all sorts of antibiotic decreased significantly for UU and MH compound infection. Conclusion UU is the major pathogeny for genitalia and urethra infection .UU, MH and UU+MH have different antibiotic susceptivities. Doxycycline and Josamycin are best therapy remedy, and the second selection is Minocycline. 　　Key words: Mycoplasma; Drug resistance; Urogential infect