第八章治疗药物浓度监测(国外英文资料).docVIP

第八章治疗药物浓度监测(国外英文资料) Chapter viii monitoring of drug concentration ? This chapter: Drug metabolism and monitoring (1) the basic process of drug operation in the body (2) basic concepts of drug generation dynamics (3) the main factors affecting the concentration of blood drugs and the effect of the drug (4) clinical indications for drugs and clinical indications for clinical need for monitoring Treatment of drug monitoring (1) time and attention of specimen collection (2) the type and principle of measuring method are commonly used Therapeutic drug monitoring (TDM) refers to the application of a certain analysis technology to determine the concentration of the drug in the body fluids, based on the theory of pharmacokinetic and electronic computer for computing tools, the process of study drug in the body, make the clinical medication individualized, scientific and reasonable. Whether it is the therapeutic effect of the drug or the adverse reaction, it is essentially the interaction between the drug and the target receptor. When the drug reached a distribution balance in the body, the blood and target drug concentrations were not always equal, but there was a correlation between the concentration of blood drug and the drug effect. Therefore, the concentration of blood drug, which is relatively easy to collect, can be used instead of the feasible basis of the concentration of target drug, such as heart, brain and kidney. The basic process of the operation of the drug Methods: oral, muscle injection, intravenous injection, intravenous drip, sublingual medicine and skin medicine. The basic process of drug operation in the body is the main process of absorption, distribution, biological transformation and excretion. For the dosage of intravenous injection, drip, such as oral, skin to give medicine there is drug absorption mechanism, including the passive diffusion, facilitated diffusion and active transport. (1) drug absorption The concept: It is the process by which the