血管性认知障碍地研究进展_王茜_徐玉振_刘运林.pdfVIP

·168 · 中华脑科疾病与康复杂志(电子版)2016 年6 月第6 卷第3 期 Chin J Brain Dis Rehabil (Electronic Edition)，June 2016，Vol． 6，No． 3 ·综述 · 血管性认知障碍的研究进展 王茜1 徐玉振2 刘运林2 【摘要】 血管性认知障碍包含一系列脑血管因素相关的认知紊乱。血管性认知障碍是全球第 二大认知障碍类型，给社会和家庭带来了沉重的负担。本文主要综述血管性认知障碍的病因、病理机 制、诊断和治疗。大部分脑血管认知障碍可归因于可控的危险因素、不可控的危险因素及其他危险因 素。血管性认知障碍病理机制复杂，主要包括脑白质损伤及脑卒中、血脑屏障与神经血管单元的破坏 及炎症和氧化应激。血管性认知障碍的治疗包括药物治疗和非药物治疗。本综述旨在为血管性认知 障碍的基础、临床研究提供参考。 【关键词】 认知障碍; 痴呆，血管性; 进展 1 2 2 1 Research progress in vascular cognitive impairment Wang Qian ，Xu Yuzhen ，Liu Yunlin . Dep artment 2 of Central Laboratory ，Dep artment of Neurology ，Taian City Central Hosp ital ，Taian 271000 ，China Corresp onding author :Liu Yunlin ，Email :bb0538 @ 126． com 【Abstract 】 Vascular cognitive impairment (VCI)comprises a range of cognitive disorders related to cerebral vessel disease． VCI is the second largest type of cognitive impairment ，which poses a heavy burden on society and families． This review highlighted the etiology ，pathologic mechanisms ，clinical diagnosis and treatment of VCI． Majority of VCI are secondary to uncontrollable risk factors ，controllable risk factors and other risk factors． The pathology mechanism of VCI is complicated including cerebral white matter damage and cerebral stroke ，the damage of blood brain barrier and neural vascular unit as well as inflammation and oxidative stress． The treatments of VCI include drug treatment and non-drug treatment． This review aimed at providing reference and help for future basic and clinical studies on VCI． 【Key words 】 Cognition disorders ; Dementia ，vascular ; Progress 血管性认知障碍(vascular cognitive impairment ，VCI)是 别、种族和基因等;可控的危险因素如高血压、高血糖、高血 基于共同血管病因