β-淀粉样蛋白和糖基化终产物的血清含量与脑血管病的关系.docVIP

β-淀粉样蛋白和糖基化终产物的血清含量与脑血管病的关系 【摘要】 目的 研究 人急性脑梗死（acute cerebral infarction,ACI）、脑出血（intracerebral hemorrhage，ICH）后血清β-淀粉样蛋白（β-amyloid protEin,Aβ）和糖基化终产物（advanced goycosylation end products,AGEs）的含量变化。探讨二者与脑血管病发病的可能机制。 方法 采集ACI、ICH患者血清标本， 应用 放射免疫 分析 法检测Aβ，流动注射分析法测定AGEs，同时与正常对照组比较。结果 ACI组患者Aβ（1.39±0.27）mg/ml,AGEs（13.28±1.22）μg/ml,ICH组Aβ（1.32±0.19）mg/ml,AGEs（12.97±1.43）μg/ml,正常对照组Aβ（1.05±0.17）mg/ml,AGEs（10.01±1.36）μg/ml,脑血管病组均高于正常对照组,差异具有显著性,P0.05;且Aβ和AGEs之间呈正相关关系（r=0.740,P0.01）。结论 Aβ与AGEs可能是脑血管病发病的共同危险因素，推测两因素参与脑血管损伤导致脑血管病。 【关键词】 脑血管病；β-淀粉样蛋白；糖基化终产物 Serum level of β-amyloid protEIn and advanced goycosylation end products of patients with cerebrovascular diseas ［Abstract］ Objective To investigate the variation of β-amyloid protein and advanced goycosylation end products in serum of patients with cerebrovascular disease.To explore the effects of the two factors on CVD.Methods To collect serum of patients with acute cerebral infarction （ACI） and intracerebral hemorrhage （ICH）. The level of Aβ was detected by radioimmunoassay,AGEs was detected by fluid injection,and compared with control group respectively.Results Aβ and AGEs were（1.39±0.27）mg/ml and（13.28±1.22）μg/ml in ACI group,（1.32±0.19）mg/ml and（12.97±1.43）μg/ml in ICH group,（1.05±0.17）mg/ml and （10.01±1.36）μg/ml in control group.Compared with control group,ACI and ICH groups had higher levels of Aβ and AGEs（P0.05）.There was positive correlation between the serum levels of Aβ and AGEs（r=0.692,P0.01）.Conclusion Aβ and AGEs may all join in pathogenesis of CVD,that may be infered the two factors hurt blood vessel of brain and cause CVD. ［Key words］ cerebrovascular disease;amyloid β-protein;goycosylation end products 脑血管病是神经系统常见病和多发病,死亡率约占所有疾病的10%,是 目前 人类疾病三大死亡原因之一,50%～70%的存活者遗留瘫痪或失语等严重残疾,给 社会 和家庭带来沉重负担［1］。本文通过测定脑血管病（cerebrovascular disease,CVD）患者血清β-淀粉样蛋白（β-amyloid,Aβ）和糖基化终产物（advanced goycosylation end products,AGEs）含量探讨两者对CVD的 影响 ，以干预CVD的临床 治疗 效果。 1 资料与方法 1.1 一般资料 选取山东大学临床学院济南市中心 医院 神经内科住院急性脑血管病患者，均在起病1周内入院，由脑CT