基于 DNA 微阵列的基因表达数据管理和分析.pdfVIP

DNA 029129 2002 10 DNA DNA DNA DNADNA microarray, DNA 2 1cm DNA Ed Southern Southern blot Bains W.DNA1995 cDNA1998 Affymetrix 13.5 DNA DNA 1999 Nature DNA SNP DNA 1 2 DNA 1 DNA cDNA Cy3 Cy5 Cy3 Cy5[Quackenbush, 2001]Cy3 Cy5 RNA1 3 1 RNA Cy3 Cy5 2 mRNA Cy5 Cy3 1 1 LOWESS() 3 Chen RNA T =R /G (R,Gk/ ) k k k 1 011 cDNA mRNA 1 log2