抗甲状腺药物的反感化及处理对策(国外英文资料).docVIP

抗甲状腺药物的副作用及处理对策(国外英文资料) Side effects of anti-thyroid drugs and treatment strategies Drug therapy is the most commonly used treatment for hyperthyroidism (note: the rest is surgery and isotope therapy). Antithyroid drugs (ATD) mainly includes the thiourea classes (e.g., propylthiouracil, PTU) and imidazoles (such as he azole, MM), the main side effects is leucocyte decrease, liver damage and drug rash, although the rate is not too high (1%), but sometimes can lead to serious consequences, as the patient must know something about this. Leukocyte reduction and granulocytic deficiency The total white blood cells in the peripheral blood cells are 4 ~ 10 x 109 / L, and the neutrophils account for 2 ~ 7.5 x 109 / L. When the total number of white blood cells 4 x 109 / L, neutrophils normal or slightly decreased, known as white blood cells reduce disease, the patient can have the symptom such as dizziness, fatigue, insomnia, much dream, a few patient can have no symptoms. When the neutrophil absolute value is 2.0 * 109 / L, its called granulocytopia; When the neutrophil absolute value is 0.5 x 109 / L, it is called granulocytosis. This kind of patient often is very urgent, all of a sudden high fever, chills, sore throat, headaches, joint pain, the whole body extremely weak, due to serious resistance is reduced, concurrent infection easily and quickly spread, the mortality rate is very high. JiaKangBing itself and anti-thyroid drugs can cause leukopenia, severe cases can lead to lack of granulocyte life-threatening, therefore, more attention must be paid to the hyperthyroidism patients on regular routine blood test, to ensure the safety of treatment. By comparing the results of routine blood tests before and after taking the drug, it also helps to identify the causes of leukocyte reduction. If its caused by hyperthyroiosis, the patient has a decrease in white blood cells before the drug is used. If it is caused by an anti-thyroid drug, the blood of the patient is normal