REPORT苯基噻二唑重复文献.pdf

REPORT SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME 1, 3, 4-THIADIAZOL DERIVATIVES *1 2 1 ARVIND KUMAR SINGH , MAHFOOZ LOHANI AND UMESH PRATAP SINGH 1 Kamla Nehru Institute of Management and Technology, Faculty of Pharmacy, Sultanpur UP, India 2Integral University, Lucknow, Uttarpradesh, India ABSTRACT Thiadiazoles are their derivatives exhibit a wide variety of pharmacological activities such as Antibacterial and anti-inflammatory. In the present study we have synthesized derivatives some 2,5 substituted 1,3,4- thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR, and MASS spectra data. These compounds were evaluated for varies biological activities such as antibacterial and anti- inflammatory activity. Keywords: 1, 3, 4-thiadiazoles, anti-inflammatory and, antibacterial. INTRODUCTION petroleum ether. The actual fraction was collected by regular checking of TLC. Finally the compounds were Mostly five membered aromatic system having three further purified by preparative TLC. heteroatom’s at symmetrical position have been studied because of their physiological properties (Saad, 1996, Compounds characterization (C-1 to C-7) data Nanjunda et al., 2006), it is also well established that Compound 1: [N-(5-Phenyl-[1, 3, 4] Thiadiazol-2-yl)- various derivatives of 1,3,4-t