这是一篇关于李川老师多成分药代的文献,很经典.pdf

0090-9556/09/3712-2290–2298$20.00 DRUG METABOLISM AND DISPOSITION Vol. 37, No. 12 Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics 29819/3537718 DMD 37:2290–2298, 2009 Printed in U.S.A. Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats Houfu Liu, Junling Yang, Feifei Du, Xiumei Gao, Xutao Ma, Yuhong Huang, Fang Xu, Wei Niu, Fengqing Wang, Yu Mao, Yan Sun, Tong Lu, Changxiao Liu, Boli Zhang, and Chuan Li Shanghai Institute of Materia Medica (H.L., J.Y., F.D., F.X., W.N., F.W., Y.M., Y.S., T.L., C.Li) and Graduate School (H.L., C.Li), Chinese Academy of Sciences, Shanghai, China; Tianjin University of Traditional Chinese Medicine, Tianjin, China (X.G., X.M., Y.H., B.Z.); Tianjin State Key Laboratory of Pharmacodynamics and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.Liu) Received August 5, 2009; accepted September 23, 2009 ABSTRACT: Panax notoginseng (Sanqi) is a cardiovascular herb containing primary factors limiting systemic exposure to most ginsenosides ginsenosides that are believed to be responsible for the therapeu- and their deglycosylated metabolites. In contrast with other gin- tic effects of Sanqi. The aim of this study was to evaluate rat senosides, biliary excretion of ginsenosides Ra3 and Rb1 was pas- exposure to ginsenosides after oral administration of Sanqi extr