miR-34家族——肿瘤抑制蛋白p53.pdf

HEREDITAS (Beijing) 2010 5 , 32(5): 423―430 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2010.00423 miR-34 家族——肿瘤抑制蛋白p53 高度相关的 microRNA 娄文加, 陈青, 刘立, 钱程 , , 310018 若干微小RNA(microRNA, miRNA) 与肿瘤抑制蛋白p53 高度相关, 其中miR-34 家族最具代表性。一方 面p53 可通过对miR-34 家族的调控实现对多个原癌基因如Bcl-2 、c-myc 以及细胞因子如cyclinE2 、cyclinD1 和c-Met 的抑制, 进而发挥抑癌作用; 另一方面miR-34 家族也可以通过抑制沉默信息调节子SIRTI 来进一步增 强p53 的活性。p53 与miR-34 家族之间形成的正反馈调节网络对抑制肿瘤的发生发展及恶化均起着重要的作 用。文章对p53 高度相关的miR-34 家族在肿瘤发生发展及治疗的最新进展作一论述。 miR-34 家族; p53; 反馈调节 miR-34s—a tumor suppression protein p53 highly related microRNA LOU Wen-Jia, CHEN Qing, LIU Li, QIAN Cheng Xinyuan Institute of Medicine and Biotechnology , College of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China Abstract: Several microRNAs, most representatively the miR-34, are highly related to tumor suppression protein p53. p53 exerts its tumor suppression function known as inhibiting multiple-oncogenes, such as Bcl-2 , c-myc and cell cytokines such as cyclinE2, cyclinD1 and c-Met through the regulation of miR-34. On the other hand, miR-34 enhances the activities of p53 by inhibiting silence information regulator I (SIRTI). The positive feedback regulatory network based on p53 and miR-34 families play an important role in suppression of oncogenesis and deterioration. This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment. Keywords: miR-34s; p53; feedback regulation miRNA 2125 miRNA : RNA, Lee [1] RNA II miRNA, miRNA—Lin-4 , DGCR8 RNA Drosha miRNA , 60~70 pre- miRNA miRBase(http://microrna. miRNA pre-miRNA Exportin-5 Ran sanger.a