神经心理药理学发表论文摘要英文-Neuropsychopharmacology.PDFVIP

Neuropsychopharmacology (2013) 38, 1617–1624 2013 American College of Neuropsychopharmacology. All rights reserved 0893-133X/13 Beer Flavor Provokes Striatal Dopamine Release in Male Drinkers: Mediation by Family History of Alcoholism 1 1,2 1 1 3 Brandon G Oberlin , Mario Dzemidzic , Stella M Tran , Christina M Soeurt , Daniel S Albrecht , 2,3 ,1,2,3,4 Karmen K Yoder and David A Kareken* 1 2 Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Radiology and Imaging Sciences, Center 3 for Neuroimaging, Indiana University School of Medicine, Indianapolis, Indiana, USA; Stark Neurosciences Research Institute, Indiana University 4 School of Medicine, Indianapolis, Indiana, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA Striatal dopamine (DA) is increased by virtually all drugs of abuse, including alcohol. However, drug-associated cues are also known to provoke striatal DA transmission- a phenomenon linked to the motivated behaviors associated with addiction. To our knowledge, no one has tested if alcohol’s classically conditioned flavor cues, in the absence of a significant pharmacologic effect, are capable of eliciting striatal DA release in humans. Employing positron emission tomography (PET), we hypothesized that beer’s flavor alone can reduce the 11 binding potential