利奈唑胺补救治疗成人革兰阳性菌感染性心内膜炎的临床分析.pdf

Asian Case Reports in Vascular Medicine 亚洲心脑血管病例研究, 2017, 5(1), 1-6 Published Online February 2017 in Hans. /journal/acrvm /10.12677/acrvm.2017.51001 A Clinical Analysis of Linezolid as Rescue Treatment for Adult Gram-Positive Bacterial Infective Endocarditis * Wenjing Wang, Zhen Tao , Yuying Shen, Yanliang Zhang, Huiling Wu Nanjing Medical University Affiliated Hospital, Nanjing Jiangsu th th th Received: Feb. 8 , 2017; accepted: Feb. 25 , 2017; published: Feb. 28 , 2017 Abstract Objective: Retrospective study was carried out to evaluate the efficacy and safety of Linezolid as rescue treatment for adult gram-positive bacterial infective endocarditis. Methods: The study comprised 36 patients from department of infectious disease in Nanjing hospital affiliated to Nanjing Medical University, between 2008 and 2012. Fifteen patients enrolled in L group received Linezolid as rescue treatment for infective endocarditis which were unsuccessfully treated. Other twenty-one patients received conventional antibiotic therapy (Control group). We described base- line characteristics of the study population and compared L group with control group for the effi- cacy and the safety of treatment. The data were analyzed by SPSS software. Results: The thir- ty-three patients in two groups received effective treatment. No significant differences in the cure rate (80% vs. 81%) and in mortality (6.7% vs. 9.5%) were observed. Thrombocytopenia was present in only one patient of L group, and others were well tolerated. When we ended the Linezo- lid for treatment, the patients get well from thrombocytopenia. Conclusions: Linezoli