DEX-硫辛酸-SS.pdfVIP

Communications DOI: 10.1002/anie.200904260 Drug Delivery Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells** Yu-Ling Li, Li Zhu, Zhaozhong Liu, Ru Cheng, Fenghua Meng,* Jing-Hao Cui, Shun-Jun Ji, and Zhiyuan Zhong* Drug delivery has been considered as the key to the clinical There exists a large difference in the redox potential success of numerous drugs.[1–3] In the past decade, with an aim between the mildly oxidizing extracellular milieu and the to improve chemotherapy, tremendous effort has been reducing intracellular fluids, such as the cytoplasm and the directed to the development of polymer nanoparticles for cell nucleus,[25] which renders reduction-sensitive polymers the controlled delivery of anticancer drugs, including doxor- particularly appealing for biomedical applications.[26] For ubicin (DOX) and paclitaxel (PTX).[4–12] These nanovehicles example, reduction-sensitive polymer/DNA complexes,[27] offer several unique features, such as enhancing the aqueous polyion complex micelles,[28, 29] micelles,[30] polymersomes,[31] solubility and bioavailability of the drug, prolonging the cross-linked polymersomes,[32] and degradable nanogels[33,34] circulation time, preferential accumulation at the tumor sites have been reported to achieve fast intracellular release of by the enhanced permeability and retention (EPR) effect, and DNA, siRNA, or drugs. reducing systemic side effects.[13, 1