抗原递呈细胞.pdfVIP

第三节 几类主要细胞因子 及其生物学活性 细胞因子分类 • 白细胞介素（interleukin, ILs ） • 干扰素（interferon, IFNs ） • 肿瘤坏死因子（tumor necrosis factor, TNFs ） • 集落刺激因子（colony stimulating factor, CSFs ） • 转化生长因子（Transforming growth factor,TGF) • 趋化性细胞因子（chemokine ） • 固有免疫中的细胞因子：TNF 、IL-1、 Chemokines、IL-12、IL-10，type I inteferon等 • 获得性免疫中的细胞因子：IL-2、IL-4、 IL-5、IFN- γ、TGF- β等 Cytokines of Innate Immunity Cytokine Size (kD) Principal cell source Principal cellular targets and biologic effects Tumor 17 kD; 51 kD homotrimer Macrophages, T cells Endothelial cells: activation (inflammation, coagulation) necrosis Neutrophils: activation factor (TNF) Hypothalamus: fever Liver: synthesis of acute phase proteins Muscle, fat: catabolism (cachexia) Many cell types: apoptosis Interleukin-1 17 kD mature form; 33 kD Macrophages, endothelial Endothelial cells: activation (inflammation, coagulation) (IL-1) precursors cells, some epithelial cells Hypothalamus: fever Liver: synthesis of acute phase proteins Chemokines 8-12 kD Macrophages, endothelial