急性淋巴细胞白血病低危组复发儿童临床相关性分析.pdfVIP

Abstract Objective: This paper aims to analyze the chemotherapy data of childhood acute lymphoblastic leukemia (ALL) in low-risk group in the Affiliated Hospital of Qingdao Universityandtoexploretherelevantfactorsofrecurrenceinthelow-riskchildrengroup. Methods: Selectin caseswere diagnosedasB-type low-risk group fromMay 1,2005 toApril 30, 2009 in pediatric hematology of our hospital through retrospective study and weretreatedwiththeschemeofShanghaiChildren’sMedicalCentre-AcutueLymphoblastic Leukemia-2005. In the end of September 30, 2011, the studyhas excluded the abandoned and lost follow-up cases and made a statistic analysis with the rest of data. The study contains45casesdiagnosedasB-typelow-riskALL,amon ofwhich,recurrencegroupwas consistedof6cases,3malecasesand3femalecasesrespectively.Intherestof39cases,6 caseswiththe samegenderandsimilarbody surfaceareaswere selectedascontrolgroupto collect andprocess clinical data. Independent sampleT-test was carried out to analyze the differencesamon themeanvalueoftestsamples.Allthedatainthestudyareprocessedby SPSS17.0. Results: 1.Thecomparisonofclinicaldatabetweenrecurrencegroupandcontrolgroup before treatment: there were no sharp differences (Pvalue 0.05) in general condition of attack, fusion gen and chromosome. 2. Treatment Condition: (1) M period: The treatment durationofrecurrencegroupwasmuchlonger(p=0.047).(2)Infectionfrequency:recurrence grouphas increasedrapidly (p=0.049)in Cs1,while,durationofanti-infectiontherapy was no sharp differences in the first three phases (P value 0.05). 3. The number of lumber punctuate and blood infusion: there were also no obvious differences in the number of lumber punctuate, infusion of red blood cells and platelets (P value 0.05). 4. The utilization of chemotherapy drugs: In the firs