吲达帕胺对高血压患者血管内皮细胞功效的影响.docVIP

吲达帕胺对高血压患者血管内皮细胞功能的影响 吲达帕胺对高血压患者血管内皮细胞功能的影响 2009-09-21 郭永芳　王钟林李毅夫 【摘要】目的　观察吲达帕胺对原发性轻、中度高血压患者血管内皮细胞功能的影响。方法　采用放射免疫法及镀铜镉还原比色法测定36例原发性高血压病患者口服吲达帕胺2.5～5 mg，每天一次，四周前后血浆内皮素(Endothelin，ET)及血清一氧化氮(Nitric Oxido,NO)的水平。结果　原发性轻、中度高血压患者治疗前与正常人相比，ET显著增高而NO显著降低(P＜0.05)，二者呈负相关(γ=-0.6936，P＜0.05)；治疗后血浆ET降低，NO水平升高(P＜0.01)，ET/NO比值降低。结论　吲达帕胺可改善高血压患者受损的血管内皮细胞功能。 【关键词】　原发性高血压　吲达帕胺　内皮细胞功能 The effects of indapamide on vascular endothelial function of mild to moderate essential hypertension　 Guo Yongfang,Wang Zhonglin, Li Yifu. The Second Affiliated Hospital of Hunan Medical University, Changsha 410011 【Abstract】　Objective　To observe the effects of indapamide on vascular endothelial function of mild to moderate Essential Hypertension (EH).Methods　The radioimmunoassay and copper coated cadmium reduction method were utilized to measure the serum Endothelin (ET) and Nitric Oxide (NO) Level in 36 patients with mild to moderate Essential Hypertension before and after administered indapamide 2.5～5 mg, monotherapy for four weeks.Results　The serum ET level in EH patients was markedly higher than that in the control group ［(93.48±7.72) vs (69.29±6.21) pg/mL,P＜0.01］，while the NO level was lower in EH ［（19.48±13.78) vs (39.70±10.53) μmol/L,P＜0.01］，ET and NO was negatively correlated.　(r=　-　0.693 6,P＜0.05). After four week　′　s treatment of indapamide,the serum ET concentration of EH patients decreased ［from (93.48±7.72) to (77.02±6.82) pg/mL,P＜0.01］ while the NO level increased ［from (19.48±13.78) to (28.15±16.89) μmol/L,P ＜0.01］ significantly, ET/NO ratio descended.Conclusion　 These results suggest that the patients of EH exist the endothelial dysfunction,indapamide can improve the endothelial dysfunction when it decrease the blood pressure. 【Key words】　　Essential hypertension　Indapamide　Endothelial function 　　吲达帕胺(Indapamide)是一种具有利尿和钙离子拮抗作用的降压药物，有多种心脏保护作用。高血压病患者存在血管内皮功能失调，与高血压的发病机理和临床治疗均有密切关系。本文观察了吲达帕胺降压治疗对反映血管内皮细胞功能的两个主要的血管活性物质即内皮素和一氧化氮的影响，探讨其对血管内皮细胞功能的作用。 对象与方法 1.对象 　　根据WHO 1996年高血压诊断