艾司西酞普兰联合米氮平治疗难治性抑郁症临床观察.docVIP

艾司西酞普兰联合米氮平治疗难治性抑郁症临床观察 　　【摘要】 目的：探讨分析艾司西酞普兰联合米氮平治疗难治性抑郁症效果。方法：选择2013年6月-2015年5月门诊及住院的114例难治性抑郁症患者，将其随机分为观察组（57例）和对照组（57例），观察组患者应用艾司西酞普兰联合米氮平，对照组患者单纯应用艾司西酞普兰，对比两组患者治疗前及治疗后2、4、6、8周的HAMD（汉密顿抑郁量表）以评估治疗效果，采用副反应量表（TESS）评估药物不良反应。结果：观察组治疗总有效率明显高于对照组，差异有统计学意义（P0.05）。结论：艾司西酞普兰联合米氮平治疗难治性抑郁症效果优于艾司西酞普兰单用，两药联用药物副反应无明显增加 【关键词】 难治性抑郁症； 艾司西酞普兰； 米氮平； 效果 中图分类号 R749.4 文献标识码 A 文章编号 1674-6805（2016）27-0006-03 Clinical Observation of Escitalopram Joint Mirtazapine in Treatment-resistant Depression/HUANG Shao-ya，CHEN Xu-xian，LIN Feng，et al.//Chinese and Foreign Medical Research，2016，14（27）：6-8 【Abstract】 Objective：To investigate the effect of Escitalopram combined with Mirtazapine in the treatment of refractory depression.Method：114 cases of refractory depression patients in outpatient and inpatient of our hospital from June 2013 to May 2015 were selected and randomly divided into observation group（57 cases） and control group（57 cases）.The observation group was treated with Escitalopram joint Mirtazapine，the control group was given a simple application of Escitalopram.HAMD（Hamilton depression scale） was compared between the two groups of patients before treatment and two weeks，four weeks，six weeks，eight weeks after treatment in order to evaluate the treatment effects.Treatment emergent symptom scale（TESS） was used to assess the adverse drug reactions.Result：The total effective rate of the observation group was significantly higher than that of the control group，the difference was statistically significant（P0.05）.Conclusion：Escitalopram joint Mirtazapine in the treatment of refractory depression is better than Escitalopram alone.The side effects associated with the combination use of the two drugs don’t increase significantly. 　　【Key words】 Refractory depression； Escitalopram； Mirtazapine； Effect First-authors address：Institute of Neurological and Mental Disease Prevention of Fuzhou，Fuzhou 350008，China doi：10.14033/j.cnki.cfmr.2016.27.003 抑郁症是一种高自杀率、高患病率、高致残率的严重精神疾病，其中