淋巴肿瘤P388D1细胞表达膜蛋白之间热休克蛋白C-端系统发育多样性歧视候选人,70序列原始研究论文.pdf

Molecular Immunology 48 (2010) 191–202 Contents lists available at ScienceDirect Molecular Immunology j o u rn al h omepage: w w w. elsev /locate/moli mm Lymphoid neoplastic P388D1 cells express membrane protein candidates that discriminate among the C-terminal phylogenetic diversity in heat shock protein 70 sequences Fumito Tani a,b,∗ , Satoshi Nishikawa b,1, Itsumi Yokoyama b,2 , Kei Hashimoto b , Masahiro Nakamoto b , Masayo Nomura b,3 , Yufeng Tao b,4 , Naofumi Kitabatake a,b a Laboratory of Global Food Science, Division of Global Environmental Resources, Graduate School of Global Environmental Studies, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, Kyoto 606-8502, Japan b Laboratory of Food Environmental Science, Division of Food Science and, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, Kyoto 606-8502, Japan a r t i c l e i n f o a b s t r a c t Article history: We previously found that mouse inducible Hsp72 bound more extensively to lymphoblast-like lymphoid Received 18 July 2010 neoplastic P388D1 cells than to RAW264.7 monocyte–macrophages. In the present study, we analyzed Accepted 13 August 2010 the characteristics of the binding to P388D1 cells of recombinant HSP70 derived from different species. Available online 28 September 2010 Recombinant mouse inducible-type Hsp72 bound extensively to P388D1cells in a saturable manner, but not to P815 mastocytoma or EL4 thy