转移性结直肠癌患者不同化疗方案的成本效益分析.pdfVIP

中华胃肠外科杂志 2008 年 3 月第 11 卷第 2 期 Chín J Gastroí盹 120 ·胃肠道肿瘤的新辅助治疗· 转移性结直肠癌患者不同化疗方案的 成本效益分析 刘天舒余一棉陈英耀 [摘要] 目的 了解治疗转移性结直肠癌的主要化疗方案 FOLFIRI(伊立替康、亚叶酸钙和 氟尿喀陡)和 FOLFOX6(奥沙利铅、亚ut酸钙和氟尿哺院)的成本效益。方法 以 V308 I临床研究 为基础，根据复旦大学附属中山医院的 2007 年第一季度的收费标准，分别计算 FOLFIRI 和 FOLFOX6 两种化疗方案序贯治疗的最小成本并进行成本效益分析。结果 在转移性结直肠癌患 者的序贯治疗中，如果→线采用 FOLFIRI 方案，二线采用 FOLFOX6 方案治疗，与相反治疗顺序相 比，每例患者的平均最小成本分别为 206365.78 元和 170468.89 元，每例患者总生存期增加 1 个 月，前者较后者多花费 39885.44 元人民币。结论 FOLFIRI 和 FOLFOX6 方案可使转移性结直肠 癌患者的总生存期延长，但治疗成本相当昂贵，FOLFOX6 方案更具成本效益比。 [关键词] 转移性，结直肠肿瘤; 化学药物治疗; 费用效益分析 Cost-efTectiveness analysis of difTerent chemotherapeutical regimens in metastatic colorectal cancer LIU Tian-s缸， YU Yi-yi , CHEN Ying-yao. Department of Medica1 οncology ， Zhong古han Hospit a1, Shanghai Medïc a1 College , Fudan Universi砂， Shanghai 200032 , China Correspondence author: LIU Tianshu , E-mail: liu.tianshu@zs-hospita1.sh.cn [Abstract 1 Objective To compare FOLFOX6 and FOLFIRI regimen in the treatment of metastatic colorectal cancer with cost-effective analysis. Methods Cost-effective analysis wa写 conducted based on the efficacy results of V308 clinical trial of FOLFOX6 and FOLFIRI regimen and the medical system price in Zhongshan hospital. Results The minimal cost analysis showed FOLFIRI followed by FOLFOX6 had the cost of RMB 206365.78 Yuan for each patient during the whole treatment period , and RMB 170468.89 Yuan for the FOLFOX6 followed by FOLFIRI regimen. Incremental analysis showed FOLFIRI followed by FOLFOX6 regimen could prolong one month of overall survival with additional cost of RMB 39885 .44 Yuan in each patient while compared with the regimen of FOLFOX6 followed by FOLFIR I. Conclusions Both FOLFOX and FOLFIRI regimens are able to prolong the survival time of patients with metastatic colorectal cancer , but cost of such treatments are still quite expensive