生物药剂学与药物动力学本书数学符号注释.docVIP

一、本书数学符号注释(Glossary) α 药物体内分布的表观一级速度常数（Apparent first-order distribution rate constant for a drug that confers upon the body the characteristics of a multicompartent model） β 多房室模型描述药物消除的表观一级速度常数（Apparent first-order elimination rate constant for a drug that confers upon the body the characteristics of a multicompartent model, obtained from the terminal slope of a semilogarithmic plot of drug concentration in the plasma versus time） τ 给药间隔时间 (Dosing interval) A 吸收表面积 (The area of absorption) AUC 血药浓度-时间曲线下面积(The area under the drug concentration in the plasma versus time curve) C 时间t的血药浓度(Drug concentration in the plasma at time t) dC/dt 血药浓度的变化率(Rate of change of drug concentration in the plasma) 血药浓度-时间曲线下总面积(Total area under the drug concentration in the plasma versus time curve) 血药浓度-时间曲线下时间从零到t的面积(Area under the drug concentration in the plasma versus time curve from time zero to T) Cav 稳态时“平均”血药浓度(Average drug concentration in the plasma at steady state upon multiple dosing) Cmax 一次给药后，峰血药浓度(Maximum drug concentration in the plasma following administration of a single dose) Cn 经n次给药，间隔期间任一时间t的血药浓度(drug concentration in the plasma at any time t during the n-th dosing interval) Css 零级过程输液后稳态时的血药浓度(drug concentration in the plasma at steady state following zero-order infusion) C0 静注后瞬间的药物浓度(drug concentration in the plasma immediately following intravenous injection) (C1)max 多次给药首次的最高血药浓度(Maximum drug concentration in the plasma after the first of a series of repetitive doses) (C1)min 多次给药首次的最低血药浓度(Minimum drug concentration in the plasma after the first of a series of repetitive doses) 多次给药达稳态时某一给药间隔的任一时刻的血药浓度(Drug concentration in the plasma at any time t during a dosing interval at steady state upon multiple dosing) 稳态时某一给药间隔期内血药浓度-时间曲线下面积(Area under the drug concentration versus time curve during a complete dosing interval at steady state upon multiple dosing) 稳态时某一给药间隔期间最高血药浓度(Maximum concentration of drug in the plasma