OPN与骨肉瘤综述.pdf

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OPN与骨肉瘤综述

Med Oncol (2015) 32:449 DOI 10.1007/s12032-014-0449-y REVIEW ARTICLE Role of osteopontin in osteosarcoma Yu-sheng Li • Zhen-han Deng • Chao Zeng • Guang-hua Lei Received: 6 December 2014 / Accepted: 9 December 2014 Springer Science+Business Media New York 2014 Abstract The primary bone malignancy osteosarcoma Introduction (OS) is a painful health burden, of which treatment remains a challenging problem. Identification of specific tumor Osteosarcoma (OS) is the most common primary bone biomarkers may help to investigate and develop the novel malignancy in children and adolescents. It arises around the effective therapeutic approaches that have specific molec- metaphysis of tubular long bones that exhibits osteoblastic ular target for the treatment of patients with OS. Osteo- differentiation, and generates immature bone [1, 2]. The other pontin (OPN), a phosphorylated glycoprotein, is involved most common sites of OS are femur, tibia and humerus. It is in many biological processes, such as biomineralization, reported to be the eighth leading form of childhood cancer bone remodeling and immune responses and has recently with an incidence of 4.4 per million. The frequency of OS is been reported to be associated with OS pathogenesis. higher in males (5.4/million/year) than in females (4.0/mil- Interestingly, both of the up- and down-regulation of OPN lion/year) and slightly higher frequent in Blacks and His- are involved in OS. During OS development, genetic or panics than Caucasians [3]. Pain is the most common early epigenetic disruption causes reduced expression of RUNX2 symptom of OS and can even lead to fracture of the affected and OPN through the up-regulation of notch signaling bone [2]. The exact etiology of OS is unclear

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